Contents
What is the microbiome?What are the benefits of an intestinal cleanse?Myths & facts about intestinal cleansingsWhat makes a good intestinal cleansings?Our test resultsScience magazines on television, free advice in pharmacies and, of course, on the internet, especially on social media: hardly any other health topic is currently receiving as much attention from the general public as the gut. But why?
What scientists have known for years is now becoming increasingly apparent to the average consumer: our digestive organ is responsible for much more than just breaking down food. It also plays a key role in our well-being.
Summary
- Scientists worldwide agree: the gut and the bacteria living in it have a major influence on the entire body.
- For this reason, so-called probiotics are becoming increasingly popular.
- Despite their diversity, there are some fundamental quality criteria that we have used to test popular products.
Go directly to the test
In this context, there is a growing number of articles online about promising intestinal cleansing, colonic irrigation or even detoxification programmes. The range of corresponding products on the market is large.
But what exactly is an intestinal cleanse? And can the manufacturers' preparations, some of which are complex and designed to last several weeks, really deliver what they promise?
What is the microbiome and what does it have to do with intestinal cleansing?
A term that anyone interested in intestinal cleansing is bound to come across is the so-called microbiome. This refers to the community of microorganisms living in the intestine. This ecosystem is unique to each individual – like a fingerprint. The microbiome uses the mucus layer produced by the intestinal epithelium as a breeding ground, but at the same time it also forms a kind of protective barrier against pathogens.
Today, we know that around 70 per cent of all immune cells are located in the gut. Around 80 per cent of all immune responses take place here.
According to studies, symptoms with mysterious causes such as frequent fatigue, digestive or skin problems, a weak immune system or even weight problems can be related to a disturbance in this very microbiome. The gut microbiome can therefore be described as the foundation of our health.
However, even the most stable foundation can be affected over time. Various factors such as stress, an unbalanced diet and medication can affect not only the microbiome itself, but also the underlying layers of the intestinal wall1. Experts refer to this type of imbalance in the gut as dysbiosis. It limits the diversity and number of "good" bacteria, allowing "bad" bacteria to gain the upper hand.

Studies show that such an altered microbiome can have a negative effect on the intestinal mucosa – and vice versa2. Intestinal cleansings are therefore generally designed to restore the balance of the microbiome while supporting the intestinal mucosa in order to ensure normal interaction between these two layers of the intestinal wall.
What is the purpose of an intestinal cleansing?
As the topic of intestinal health and the many connections between the intestine and our well-being are becoming increasingly apparent to the public, there are now numerous tips available online on how to restore the function and security of our "foundation of health". The most frequently mentioned remedy of choice is the intestinal cleansing mentioned earlier.
The methods described online form a veritable sea of information, making it almost impossible for people who want to cleanse their intestines to keep track of everything and find reliable advice.
To make matters worse, the market has been flooded in recent years with products that sometimes make big promises. These are mostly probiotic products, i.e. preparations containing live bacteria that are supposed to enable intestinal cleansing with comparatively little effort. They are available in all shapes, colours – and, of course, price ranges.
But how does an intestinal cleanse work?
A vivid comparison can be used to explain the principle behind an intestinal cleansing. Like a wildflower meadow teeming with different plants, herbs, insects and animals, every human being's microbiome is a unique mixture of bacteria that exist in a delicate state of equilibrium.
This harmonious interaction is subject to natural fluctuations within certain limits throughout our lives. Similar to a flower meadow throughout the changing seasons, the microbiome also undergoes completely normal changes.
However, persistent negative influences, such as stress, an unhealthy diet or even the use of medication, can permanently disrupt this ecosystem. The landscape is virtually barren. Probiotic preparations are then used to introduce as many new seedlings as possible in the form of living bacterial cultures, so that they can settle there and "replenish" the microbiome.

In short: On the one hand, specific intestinal bacteria (known as probiotics) should be administered in a targeted manner and in high doses, thereby restoring the intestinal microbiome to its equilibrium and optimally supporting the intestine in fulfilling its tasks. On the other hand, ideally, different ingredients should also address the intestinal mucosa – for all-round well-being.
This sounds very plausible at first glance, but is there really any truth to it?
Myths and facts about colon cleansing
As with any hype, numerous myths and claims quickly arose about the probiotics contained in intestinal cleansers, making it even more difficult to choose the right product.
We take a closer look at the most widespread myths:
Myth 1: All probiotics are the same
Fact 1: We can answer this myth with a clear "false".
The various intestinal cleansings we examined differed greatly from one another. This was particularly evident, for example, in the number and selection of bacterial strains examined, as well as in the dosage and packaging. All these criteria ultimately determine the quality of a product.
Myth 2: Probiotics cannot restore the gut because they are broken down by stomach acid and therefore do not reach the gut alive
Fact 2: Not true.
In fact, some bacteria, especially bifidobacteria and lactic acid bacteria, are resistant to stomach acid.
Although this may sound surprising at first, it is logical – after all, the bacteria already present in our intestines, which we have ingested through our diet, have also travelled this path and arrived alive. Therefore, enteric-coated capsules containing bacteria that occur naturally in the gut are unnecessary for such products.

Myth 3: An intestinal cleansing is unnecessary because probiotics provide hardly any more bacteria than our conventional diet
Fact 3: This myth is also not true.
There are certainly foods with probiotic properties; for example, yoghurt, sauerkraut and the currently popular Korean kimchi contain lactic acid bacteria. However, the diversity and variety of bacteria in food is quite low. In addition, many products are pasteurised, which kills bacteria (both good and bad).
Good preparations, on the other hand, contain at least 20 billion colony-forming units (CFU) per capsule.
Myth 4: The influence of the microbiome is overestimated, so gut cleanses are nonsense
Fact 4: Not really true.
Numerous studies have proven the connection between the microbiome and health.
A team of researchers from Chicago showed that mice with weakened immune systems had a much higher chance of survival after contact with pathogens when they were given the microbiome, i.e. the microorganisms, of healthy mice3. Similar studies have also been conducted on topics such as allergies4 and fatigue5.
Myth 5: A good preparation cleanses the intestines immediately!
Fact 5: Not really.
The idea behind an intestinal cleansing is to support the intestine in the long term.
Considering the extraordinary number of bacteria in our intestines, it is clear that significant results cannot be achieved overnight. Although some people notice slight changes after the first week (especially in terms of digestion), micronutrient experts such as Martin Gschwender recommend consumption over a period of at least three months.
What constitutes an intestinal cleansing and which preparations meet our requirements?
What makes a probiotic and which products fulfil our requirements?
In the course of their research, the expert team identified 5 key quality features and then tested 5 products for these features.
Quality characteristic 1: The number of bacterial strains contained
A good probiotic endeavours to come as close as possible to the composition of a balanced human intestinal microbiome. In principle, it should mimic a faecal transplant - but without the disgust factor. However, a human gut does not only harbour 3 to 10 different bacterial strains, but far more. Accordingly, it should contain at least 50 different strains.1
Quality characteristic 2: The dosage of colony-forming units
Although figures such as 2, 4 or 10 billion CFU sound very impressive at first, current research shows that a healthy gut contains 10 to 100 trillion bacteria. Preparations with too low a dosage are therefore not significant enough to actually bring about a change. Our expert recommends products with at least 20 billion CFU.2
Quality characteristic 3: Support for the intestinal mucosa
In order for the microcultures to colonise the intestine and do their work there, they need a suitable breeding ground: an intact intestinal mucosa. The problem is that the intestinal mucosa is often damaged, especially in the case of intestinal problems, which makes it difficult for the good bacteria to colonise.
In addition to bacteria, probiotics should therefore also contain substances that support the intestinal mucosa, such as the B vitamins niacin and biotin. A product containing at least two such substances will be awarded 100 points, whereas products containing one such substance will be awarded 50 points.
Quality characteristic 4: The stability of the packaging
The bacteria in a probiotic are put into a kind of hibernation during production by freeze-drying. When they come into contact with moisture, they "wake up". If suitable food sources are then available - which is the case in the intestine - the bacteria thrive. The problem is that many forms of packaging do not adequately protect the preparations from moisture.
For example, if capsules are not packaged individually but together in a plastic container or jar, the products come into contact with air or moisture every time they are opened. As a result, the bacteria can awaken too early, but then find no food in the capsule - and starve to death.
Plastic packaging is made even more difficult by the fact that the material does not completely keep out moisture: Tiny amounts of moisture can pass through the packaging. In these cases, it is therefore not uncommon for all the bacteria contained in the packaging to be dead by the time it is ingested.
Aluminium-aluminium blister packs, in which each capsule is individually embedded in an aluminium chamber and is therefore optimally protected, are regarded as the packaging gold standard.
Products with this kind of packaging will therefore receive full marks. In contrast, plastic blisters, while still offering single-unit packaging, are made from inferior materials. As a result, products with plastic packaging will only receive 75 points.
While the properties of glass are superior to those of plastic, glass bottles usually contain a greater number of capsules, which leads to them being in contact with air and therefore moisture with every opening. Glass bottles therefore are only "worth" 50 points. Plastic bottles on the other hand combine the disadvantages of glass bottles and plastic blisters and can therefore only be awarded 25 points.

Aluminium-aluminium blisters protect bacteria in their capsules optimally from moisture.
Quality characteristic 5: Quality standards and certification
Unfortunately, there are hardly any legal requirements for the production of probiotics. For this reason, many manufacturers advertise with certifications - but these often only cover a minimum standard. It is therefore particularly important to take a closer look at the certifications advertised.
Production according to GMP (Good Manufacturing Practice), the pharmaceutical grade production standard, ensures the highest standard. Only with GMP-certified manufacturers can consumers be sure that their products have been manufactured to this particularly high standard, which is why products with this certificate will be awarded 100 points, whereas products missing it will receive zero points.
Note: The term ‘probiotic’ is widely used, but may not be used to advertise a corresponding product.
The editorial team has instead opted for the more appropriate term ‘microculture preparation’.
Based on these criteria, we analysed 5 products and came to the following conclusion:

Kijimea K53 Advance
Advantages
The manufacturer is known in medical circles for its research and innovations.
Just one easy-to-swallow capsule covers the daily dose.
The product is gluten-, fructose- and lactose-free and free from additives, preservatives, flavourings and sweeteners.
Disadvantages
The manufacturer recommends using the product over a longer stretch of time.
Kijimea K53 Advance is manufactured by the German brand SYNformulas, which is well established in bacterial research. Thanks to its own scientific research, which has even been published in the world-renowned specialist journal "The Lancet", this company enjoys a great reputation among medical experts. This is also evident when taking a closer look at the product: with 53 bacterial strains, K53 Advance offers the greatest variety.
In addition, the product has one of the highest dosages (20 billion CFU) and also contains both biotin and niacin to support the intestinal mucosa. The packaging in an aluminium/aluminium blister corresponds to the gold standard, as it optimally protects each capsule from air and moisture from production to consumption.
In addition, both the manufacturing process and the facilities on which the preparation is produced are GMP-certified in accordance with the strict pharmaceutical grade standard.
What particularly caught our eye during our research on this product are the numerous extremely positive customer reviews that underline our own impression of the product. Here are some examples:
Andrew B.
'I'm thrilled with the positive change. I highly recommend it to everyone. From fast shipping to fast results, it's GREAT!'
Fiona G.
'I've been looking for a probiotic that is produced and packaged to the highest scientific standards for a long time. If you look into it a little, it quickly becomes clear that Kijimea simply has a different quality standard than others – I'm super satisfied!!!'
Joanne M.
'I've been taking the product for a few weeks now and I already feel much better. I've also given it to a friend.'

Kijimea K53 Advance convinces across the board and therefore deservedly takes first place with 95 points.
Particularly impressive: the product contains 53 different bacterial strains, more than ten times as many as the product in second place.
Synerbio Daily High Strength
Advantages
Manufacturer mentions strain specificity.
High dosage.
Disadvantages
With four different bacterial strains, the diversity is too low.
Contains no ingredients to strengthen the intestinal mucosa.
The capsules from Synerbio share the high dosage of the test winner - but the 20 billion CFU are distributed across four instead of 53 different strains. Compared to the diversity of the human microbiome, this is a rather small number – however, the manufacturer laudably provides the strain specification.
Furthermore, the manufacturer did not add ingredients that specifically address the intestinal mucosa. On the other hand, the GMP certification, which promises compliance with high production standards, should be emphasised positively.
With FOS and Inulin, the product contains two different prebiotics, which serve as food for the bacteria, but it should be mentioned that Inulin can lead to flatulence. Although the packaging in the glass bottle offers better protection than a plastic container, it does not change the problem that air and thus moisture can get into the packaging every time it is opened.

All in all, Daily High Strength scored 45 points, securing second place behind the test winner Kijimea K53 Advance.
Although the product offers a sufficiently high dosage, the diversity of 4 strains is much lower than many of its competitors.
Buy Synerbio Daily High Strength online
luvbiotics Advanced Formula Gut Health
Advantages
Mention of the strain specificity.
The capsules are vegan, gluten-free and free from artificial flavourings and preservatives.
Disadvantages
The dosage is too low.
The manufacturer does not have GMP certification.
At first glance, luvbiotics looks very promising thanks to their 16 bacterial strains - and thus the second highest diversity after the test winner – even with the packaging in a plastic blister. Even though an aluminium-aluminium blister promises even better protection than a plastic blister, the individual packaging still protects the contents far better than a plastic container.
However, there are also significant disadvantages: First of all, the product only contains the low dosage of 8.2 billion CFU per day - a far cry from the recommended 20 billion CFU. GMP certification is also lacking, as are substances to support the intestinal mucosa. However, the addition of zinc and calcium, which is important for the function of the digestive enzymes, should be mentioned positively here.

With 30 points, luvbiotics came in 3rd.
Although the product contains 16 different strains, the dosage is too low.
Buy luvbiotics Advanced Formula Gut Health online
Jamieson Chewable Probiotic
Advantages
Pleasant to consume as the tablets can be chewed.
Mentions strain specificity.
Disadvantages
Contains the lowest dosage of all products tested.
Contains sugar.
Chewable Probiotic is the only product that is not swallowed in capsule form but consumed in the form of chewable tablets. This may be an advantage for people who have difficulty swallowing capsules, but this form brings with it another problem: The flavour becomes relevant. For this reason, the manufacturer has added natural strawberry flavouring, but also sugar.
The product contains five different bacterial strains in the lowest dosage of 2 billion CFU among the products compared here. The manufacturer commendably states the strain specificity, though. The packaging in the plastic container is not ideal, as it does not adequately protect the contents from penetrating air and moisture. Ingredients that are specifically intended to support the intestinal mucosa are not included. The GMP certification can be seen as a real plus point, as it promises high production standards.

The chewable probiotics achieve a total of only 25 points and thus rank fourth.
Although they may be able to convince one or two strawberry fans thanks to their strawberry-flavoured chewable form, both the diversity and dosage are too low to achieve a real effect on the gut microbiome.
Buy Jamieson Chewable Probiotic online
Healthy Mood Natural High Strength Probiotic Max
Advantages
At 20 billion CFU, the dosage is high.
Disadvantages
One bacterial strain is not sufficient for such a preparation.
The packaging is not ideal.
The capsules from Healthy Mood do not prove sufficient with regard to several of the key qualities a probiotic should have. The only highlight is the dosage of 20 billion CFU per capsule. On the other hand, the product contains a single bacterial strain, but does not mention the strain specificity. Ingredients that are explicitly intended to support the intestinal mucosa are absent, as is GMP certification.
The product can be purchased either in a bag or in a plastic container; neither is ideal, as neither is suitable for optimally protecting the contents from penetrating air and moisture.

With a mere 20 points, the capsules from Healthy Mood came in last.
Although they scored in the higher range for dosage, they disappointed in all other areas.
Buy Healthy Mood Natural High Strength Probiotic Max online
Conclusion
Colon cleansing is currently the health topic of the moment – and rightly so, in our opinion!
The significant influence of the gut and its bacterial inhabitants on many areas of health is already becoming apparent. At the same time, however, it is becoming apparent that today's stressful lifestyle can have a negative impact on our intestinal microbiome. In many cases, intestinal cleansing can be a useful supplement.
However, on closer inspection, it becomes clear that there are enormous differences in quality between the products available on the market. It is therefore particularly important to obtain comprehensive information before making a purchase.
1 Yu L C, Wang J T, et al. (2012). Host-microbial interactions and regulation of intestinal epithelial barrier function: From physiology to pathology. World J Gastrointest Pathophysiol. 15 February 2012;3(1):27-43. doi: 10.4291/wjgp.v3.i1.27.
2 Kinashi Y, Hase K (2021). Partners in Leaky Gut Syndrome: Intestinal Dysbiosis and Autoimmunity. Front Immunol. 22 April 2021;12:673708. doi: 10.3389/fimmu.2021.673708.
3 Kim, S. M., DeFazio, J. R., et al. (2020). Fecal microbiota transplant rescues mice from human pathogen mediated sepsis by restoring systemic immunity. Nature communications, 11(1), 2354. https://doi.org/10.1038/s41467-020-15545-w.
4 Hua, X, Goedert, J J, Pu, A, Yu, G, & Shi, J (2015). Allergy associations with the adult faecal microbiota: Analysis of the American Gut Project. EBioMedicine, 3, 172–179. https://doi.org/10.1016/j.ebiom.2015.11.038.
5 Frémont, Marc et al. (2013). High-throughput 16S rRNA gene sequencing reveals alterations of intestinal microbiota in myalgic encephalomyelitis/chronic fatigue syndrome patients., Anaerobe vol. 22 (2013): 50-6. doi:10.1016/j.anaerobe.2013.06.002.
Turnbaugh, P et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444, 1027–1031 (2006). https://doi.org/10.1038/nature05414.
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The information on this page does not constitute medical advice and should not be considered as such. Consult your doctor before changing your regular medical care. This product is not intended to diagnose, treat, cure or prevent any disease. The effect depends on individual factors. The images of those affected are based on real people whose names have been changed.
